Volume 88 Issue 23 | p. 37 | Concentrates
Issue Date: June 7, 2010

New Molecular Way To Combat The Flu

Microbiologists uncover a new protein target and a small molecule that inhibits the protein
Department: Science & Technology
Keywords: influenza A, protein target

Hong Kong microbiologists have uncovered a new protein target for treating influenza A, along with a small molecule that prevents viral replication by blocking the protein (Nat. Biotechnol., DOI: 10.1038/nbt.1638). Richard Y. Kao of the University of Hong Kong and coworkers used a forward chemical genetics approach to identify influenza A nucleoprotein as a drug target. The researchers then screened a library of more than 50,000 compounds, taking a closer look . . .

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