Volume 88 Issue 26 | p. 38 | Concentrates
Issue Date: June 28, 2010

Versatile Catalyst Delivers CF3 Groups

Palladium-mediated method adds influential moiety to a variety of molecules
Department: Science & Technology
Keywords: organometallic chemistry, palladium, trifluoromethyl, fluorine

Tack one more reaction onto the list that bulky ligands from MIT help accomplish—adding tri­fluo­ro­meth­yl groups to aromatic rings. Tri­fluo­ro­meth­yls make molecules more lipophilic and metabolically stable, among other desirable properties, so chemists in the drug and agrochemical industries are constantly trying to prepare them more efficiently. Stephen L. Buchwald and colleagues at MIT previously used a bulky, phosphine-containing ligand to install fluorine atoms on aromatic rings (C&EN, Aug. 17, 2009, . . .

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