Volume 88 Issue 29 | p. 32 | Concentrates
Issue Date: July 19, 2010

How Valproate Affects Bones

Mood stabilizer and anticonvulsant drug lowers production of two key bone proteins
Department: Science & Technology
Keywords: sodium valproate, proteomics, collagen, epilepsy, bipolar disorder

A proteomic study suggests how the epilepsy and bipolar disorder drug sodium valproate leads to bone loss: It reduces production of collagen and osteonectin, both critical proteins for bones (J. Proteome Res., DOI: 10.1021/pr1005263). Valproate has been in use for more than 40 years, mostly as an anticonvulsant or mood stabilizer. But the reason for its bone . . .

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