Volume 88 Issue 41 | pp. 34-35 | Concentrates
Issue Date: October 11, 2010

Phosphorylation And Acetylation In Action

NMR technique allows researchers to simultaneously detect posttranslational modifications taking place
Department: Science & Technology
News Channels: JACS In C&EN, Analytical SCENE
Keywords: phosphorylation, acetylation, NMR, nuclear magnetic resonance

Protein posttranslational modifications switch essential biological processes on and off, but tracking them in real time is a challenge. Now, researchers led by Philipp Selenko of the Leibniz Institute of Molecular Pharmacology, in Berlin, have developed a way to concurrently watch phosphorylations and acetylations take place (J. Am. Chem. Soc., DOI: 10.1021/ja106764y). The technique involves standard two-dimensional nuclear magnetic resonance . . .

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