Volume 88 Issue 41 | p. 35 | Concentrates
Issue Date: October 11, 2010

Tracking mRNA Particles

3-D optical imaging is used to follow mRNA particles inside yeast cells with nanometer-scale precision
Department: Science & Technology
News Channels: Nano SCENE, Analytical SCENE
Keywords: mRNA, single-molecule spectroscopy, microscopy

The motion of individual messenger RNA particles can be tracked in three dimensions with nanometer-scale precision via optical imaging, W. E. Moerner and coworkers at Stanford University report (Proc. Natl. Acad. Sci. USA, DOI: 10.1073/pnas.1012868107). Using a recently developed 3-D microscopy method with a so-called double-helix point spread function, the researchers followed the position of single mRNA particles in live yeast cells. Because yeast cells are spherical, 3-D measurements are necessary to provide . . .

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