Volume 89 Issue 15 | p. 34 | Concentrates
Issue Date: April 6, 2011

Genetic Tag For Electron Microscopy

Imaging: Biobased label enables scientists to pinpoint proteins in cells, tissues
Department: Science & Technology
Keywords: electron microscopy, protein label, diaminobenzidine photooxidation, green fluorescent protein, miniSOG

A new genetically encoded label for proteins could do for electron microscopy what green fluorescent protein has done for fluorescence microscopy, according to a report in PLoS Biology (DOI: 10.1371/journal.pbio.1001041). A research team led by chemistry Nobel Laureate Roger Y. Tsien of the University of California, San Diego, and Xiaokun Shu, now a pharmaceutical chemist at UC San Francisco, has developed miniSOG (mini singlet oxygen generator), a small fluorescent flavoprotein that . . .

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