Volume 89 Issue 18 | p. 29 | Concentrates
Issue Date: May 2, 2011

Pairing Drugs Kills Pathogens

Nonantibiotics such as Imodium and Antabuse can soup up the potency of weak antibiotics such as minocycline
Department: Science & Technology
Keywords: antibiotics, drug resistance

The antidiarrheal drug Imodium (loperamide hydrochloride) and the alcoholism-aversion drug Antabuse (disulfiram) can both soup up a weak antibiotic called minocycline so that it kills pathogens such as methicillin-resistant Staphylococcus aureus and multi-drug resistant Pseudomonas aeruginosa (Nat. Chem. Biol., DOI: 10.1038/nchembio.559). Motivated by the alarming rise of antibiotic-resistant pathogens and the pharmaceutical industry’s retreat from antibiotic drug discovery, researchers led by Eric D. Brown and Gerard D. Wright at . . .

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