Volume 89 Issue 26 | p. 36
Issue Date: June 27, 2011

Peptides Block Fibril Formation

Computationally designed inhibitors suggest general strategy to prevent the formation of disease-causing amyloid
Department: Science & Technology
Keywords: amyloids, fibrils, Alzheimer’s, proteins, peptides, structure-based design

Peptides designed to interact with a specific small fraction of an amyloid-forming protein can inhibit fibril formation by the intact protein as well, researchers at the University of California, Los Angeles, recently reported (Nature,DOI: 10.1038/nature10154).

David Eisenberg says his team’s study “validates the strategy” of looking for inhibitors of amyloid fibril formation by concentrating on a small portion of the protein. “At this point, there’s no way of determining atomic-level information for whole . . .

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