Epizyme Signs
 With Glaxo Drug Program | January 17, 2011 Issue - Vol. 89 Issue 3 | Chemical & Engineering News
Volume 89 Issue 3 | p. 19 | Concentrates
Issue Date: January 17, 2011

Epizyme Signs
 With Glaxo Drug Program

Department: Business
Keywords: cancer, histone methyltranferases, epigenetic enzymes

Epizyme and GlaxoSmithKline formed an alliance to discover, develop, and market novel small-molecule therapeutics targeting histone methyltransferases (HMTs), a class of epigenetic enzymes, for treatment of cancer and other diseases. The companies will use Epizyme’s discovery platform and chemical library. Under the terms of the agreement, Epizyme will receive an up-front payment of $20 million, as well as research funding, and is also eligible for milestone payments of up to $630 million. Epigenetic enzymes are a class of proteins that regulate whether genes are turned off or on. Targeting specific HMTs with small-molecule therapeutics could allow control of gene expression pathways that contribute to diseases.

Chemical & Engineering News
ISSN 0009-2347
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