Volume 89 Issue 35 | p. 33 | Concentrates
Issue Date: August 29, 2011

More Hits Tallied For Cardiac Amyloidosis

Department: Science & Technology
News Channels: Biological SCENE
Keywords: transthyretin, cardiac amyloidosis, fluorescence polarization

Although FDA has yet to approve any drugs for the treatment of transthyretin-based cardiac amyloidosis, a disease caused by aggregation of proteins in the heart, a study adds more candidates to the list of possibilities (Sci. Transl. Med., DOI: 10.1126/scitranslmed.3002473). Transthyretin is a tetrameric protein that transports the hormone thyroxine throughout the body. When the protein becomes unstable, particularly because of a mutation, it aggregates and can cause heart arrhythmia and failure. Current transthyretin-stabilizing . . .

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