Volume 89 Issue 35 | p. 5 | News of The Week
Issue Date: August 29, 2011

Prefab Synthesis Moves Ahead

Organic Chemistry: First stable α–boryl aldehydes ease preparation of complex small molecules
Department: Science & Technology
Keywords: a-boryl aldehyde, coupling, MIDA boronate, PIDA boronate, organic synthesis

Two studies report the first isolation of α-boryl aldehydes, bifunctional reagents that facilitate synthesis of organic compounds that were previously difficult or impossible to make. The work could enable nonexperts in synthesis to rapidly compose complex organic molecules from simple building blocks in an automated manner—similar to the way peptides are made today.

α-Boryl aldehydes are usually extremely unstable, but newly discovered stable ones are now stored in bottles in Andrei K. Yudin’s lab . . .

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