Volume 89 Issue 42 | p. 54 | Concentrates
Issue Date: October 17, 2011

Proteoglycan Is Sugar-Specific

Mass spec of highly purified polysaccharide chains reveals simplest proteoglycan has a defined sugar sequence
Department: Science & Technology
News Channels: Biological SCENE
Keywords: mass spectrometry, proteoglycans, polysaccharides

The proteoglycan bikunin has a defined sequence of sugar units in its polysaccharide chains, chemists at Rensselaer Polytechnic Institute, the University of Georgia, and Japan’s Chiba University report (Nat. Chem. Biol., DOI: 10.1038/nchembio.673). Proteoglycans are proteins ornamented with long, sulfated polysaccharide chains known as glycosaminoglycans (GAGs). Bikunin, a serine protease inhibitor used in Japan as a drug to treat pancrea­titis, is the simplest proteoglycan, with just one . . .

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