Volume 89 Issue 43 | pp. 10-17
Issue Date: October 24, 2011

Cover Story: Drug Development

The Bryostatins’ Tale

With the promise of treating cancer, Alzheimer’s, and HIV this family of marine natural products continues to intrigue scientists more than four decades after its discovery
Department: Science & Technology | Collection: Life Sciences
News Channels: Biological SCENE
Keywords: Bryostatin, Protein Kinase C, natural products, cancer, Alzheimer’s disease, HIV

One June day in 1968 marine biologist Jack Rudloe went down to collect specimens from the docks at his local marina on the northern Florida coast of the Gulf of Mexico. As the man behind Gulf Specimen Co., Rudloe was used to catching some of the Gulf’s more interesting creatures—electric rays, bonnethead sharks, and live jellyfish—for aquariums and research centers throughout the country. But on this day, his mission was simpler: . . .

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