Volume 89 Issue 43 | p. 7 | News of The Week
Issue Date: October 24, 2011

Modifying Messenger RNA

Chemical Biology: Methylated bases in mRNA may have roles in gene regulation and obesity
Department: Science & Technology
News Channels: Biological SCENE
Keywords: exotic RNA, gene expression, obesity

For decades researchers have known that every strand of messenger RNA in a cell has five or six adenosine bases that are methylated, but nobody could figure out why this ubiquitous decoration exists.

Now a team of scientists led by Chuan He at the University of Chicago have found an enzyme that can remove the methyl group from mRNA. This first report that RNA bases can be reversibly modified suggests that RNA . . .

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