Volume 89 Issue 48 | p. 35 | Concentrates
Issue Date: November 28, 2011

How A Horseradish Sensor Helps Tylenol Work

Drug’s breakdown products activate sensor protein in mice’s spinal cords
Department: Science & Technology
News Channels: Biological SCENE
Keywords: Acetaminophen, ion channels, pain, electrophysiology

Acetaminophen exerts its pain-relieving effects with help from a cation channel protein called TRPA1, according to studies conducted in rodents (Nat. Commun., DOI: 10.1038/ncomms1559). The discovery suggests that TRPA1 could be a viable target for new pain relievers. Also known as paracetamol, acetaminophen is one of the most widely used analgesics. But how it works is still unclear. Among the drug’s proposed targets . . .

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