Volume 89 Issue 6 | p. 26 | Concentrates
Issue Date: February 7, 2011

Sugar Rules For Protein Drugs

Guidelines show protein-drug designers where they can install sugars to improve stability and pharmacokinetics
Department: Science & Technology
Keywords: glycosylation, biologic, drug design

A simple list of engineering rules promises to make it easier for drug designers to use sugars to stabilize protein-based drugs (Science, DOI: 10.1126/science.1198461). Boosting the stability of these drugs is expected to increase their half-life and thus potentially decrease how frequently patients must inject them, says Jeffery W. Kelly of Scripps Research Institute, who developed the rules with Scripps colleague Evan T. Powers. The rules point drug designers . . .

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