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Web Date: June 2, 2011

Detecting A Bacterial Toxin's Glow

Synthetic Sensors: New probe fluoresces when it binds to a common bacterial molecule
Department: Science & Technology
News Channels: JACS In C&EN, Analytical SCENE
Keywords: endotoxin, fluorescent sensor, lipopolysaccharide

When bacterial endotoxins, building blocks of the outer membrane in many disease-causing bacteria, enter the human body, they spur an immune response and can lead to sepsis. Now researchers have built a simple lipid-based sensor that glows in the presence of bacterial endotoxins (J. Am. Chem. Soc., DOI: 10.1021/ja204013u).

Bacterial endotoxins, also called lipopolysaccharides, consist of negatively charged sugars attached . . .

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