Web Date: October 10, 2011
New Method Isolates Membrane Proteins
Chemists have a new way using lipid bilayers to separate insoluble membrane proteins (Anal. Chem., DOI: 10.1021/ac201768k). The technique could help scientists study the function of these often difficult-to-handle proteins, including enabling research on pharmaceutically relevant properties such as how small molecules bind to them, the researchers say.
To get membrane proteins into solution for standard purification methods, chemists typically add detergents and sonicate the mixture. But this process can disrupt the proteins’ structures . . .
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