Volume 90 Issue 13 | p. 46 | Concentrates
Issue Date: March 26, 2012

Indole Triggers Bacterial Persistence

Bacterial signaling molecule turns on protective response
Department: Science & Technology
News Channels: Biological SCENE
Keywords: bacteria, infections, persistence, antibiotics

Bacterial persisters—dormant cells with a high tolerance for antibiotic treatment—are prime culprits in chronic and recurrent infections. James J. Collins and coworkers at Boston University show that indole-based bacterial communication plays a key role in increasing bacterial persistence (Nat. Chem. Biol., DOI: 10.1038/nchembio.915). They incubated cultures of Escherichia coli with physiological levels of indole for one hour and then treated the cultures with high levels of . . .

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