Volume 90 Issue 16 | p. 41 | Concentrates
Issue Date: April 16, 2012

Precatalytic Intron Structure Solved

Pre- and postcatalytic structures of a self-splicing RNA molecule (the group II intron from a bacterium) are similar
Department: Science & Technology
News Channels: Analytical SCENE, Biological SCENE
Keywords: RNA, intron, splicing

The first crystal structure of the precatalytic state of a group II intron has been solved (Nat. Struct. Mol. Biol., DOI: 10.1038/nsmb.2270). Previous structures of these self-splicing RNA molecules, which are thought to be evolutionary predecessors of the spliceosome, have captured them either during or after the splicing process, but never before splicing starts. Navtej Toor of the University of . . .

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