Volume 90 Issue 18 | p. 35 | Concentrates
Issue Date: April 30, 2012

Computer Design Leads To Cystic Fibrosis Drug Candidates

Computer method based on custom-designed peptides that block protein binding interactions
Department: Science & Technology
News Channels: Biological SCENE
Keywords: cystic fibrosis, computational drug design

Starting with the structure of a protein related to cystic fibrosis, Duke University computational chemists have gone from theory to possible drug candidates for the disease (PLoS Comput. Biol., DOI: 10.1371/journal.pcbi.1002477). Cystic fibrosis is an inherited condition in which mucus builds up in the lungs and digestive tract, making it difficult to breathe and absorb food nutrients. The underlying cause is a . . .

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