Volume 90 Issue 18 | p. 11 | News of The Week
Issue Date: April 30, 2012

Streamlining Tetrazine Synthesis

Organic Chemistry: Lewis acids ease synthesis of biochemical probes
Department: Science & Technology
Keywords: bioorthogonal chemistry, chemical biology, tetrazine, molecular probes

Facile synthesis of promising tetrazine biochemical probes could be a big step forward for researchers who examine biochemistry as it happens in cells and live animals (Angew. Chem. Int. Ed., DOI: 10.1002/anie.201201117). The advance, utilizing Lewis acid catalysts, might allow more researchers to make the probes in one pot from commercially available starting materials.

Thus far, the tetrazine labels, which feature nitrogen-rich rings, have . . .

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