Volume 90 Issue 22 | pp. 52-53
Issue Date: May 28, 2012

New Way To Modify DNA

Zinc finger nickases may challenge zinc finger nucleases as genomic change agents
Department: Science & Technology
News Channels: Materials SCENE, Biological SCENE
Keywords: zinc-finger nuclease, zinc-finger nickase, endonuclease, DNA, DNA cleavage, gene therapy

Zinc finger nickases are the new kids on the block in the DNA-modification neighborhood. This class of DNA change agents could supplement or even supplant the more established zinc finger nucleases for some research and therapeutic applications, scientists say—but only if they can be improved. Right now that is a big “if.”

Zinc finger nucleases are synthetic proteins that are widely used to modify genes by making site-selective, double-strand breaks in genomic DNA. But they . . .

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