Volume 90 Issue 29 | pp. 42-43
Issue Date: July 16, 2012

Theoretical Framework To Explain Effects Of Aqueous Ions On Proteins Remains Elusive

After decades of study, researchers struggle to explain the ordering of aqueous ion effects on proteins
Department: Science & Technology
News Channels: Biological SCENE
Keywords: Hofmeister effect, ions in solution, proteins, solvation

For Jifeng Zhang, research adviser for bioproduct pharmaceutical development at Eli Lilly & Co., the solvation of ions in water has decidedly practical implications.

The topic may appear arcane and academic, yet the behavior of aqueous ions has profound effects on biological molecules such as proteins and DNA and, thus, implications for health and disease.

For example, Zhang says, patients with inflammatory disease may receive a solution of monoclonal antibodies. . . .

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