Volume 90 Issue 3 | p. 30 | Concentrates
Issue Date: January 16, 2012

Easier Difluoromethylation

New reagent adds CF2H moiety to nitrogen-containing heteroarenes, as well as to thiols and enones
Department: Science & Technology
News Channels: JACS In C&EN
Keywords: difluoromethyl, heteroarene, thiol, enone, radical, fluorination

A reagent that directly difluoromethylates nitrogen-containing heteroarenes, as well as certain thiols and enones, has been reported by Phil S. Baran of Scripps Research Institute and colleagues (J. Am. Chem. Soc., DOI: 10.1021/ja211422g). The compound, Zn(SO2CF2H)2, is air-stable and works at room temperature. It’s amenable to gram-scale procedures, according to the inventors, and it could be used to make novel pharmaceuticals or materials with . . .

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