Volume 90 Issue 40 | p. 52 | Concentrates
Issue Date: October 1, 2012

Copper Continues To Advance Trifluoromethylation

Two groups report new copper-catalyzed reactions for adding trifluoromethyl groups to organic substrates
Department: Science & Technology
News Channels: Materials SCENE, Environmental SCENE
Keywords: trifluoromethyl, fluorination, fluoroform, copper

Copper-promoted trifluoromethylation reactions have been successful during the past three years, and researchers continue to broaden the scope of the chemistry and streamline procedures. Vladimir V. Grushin and coworkers at the Institute of Chemical Research of Catalonia, in Spain, now report a new synthesis of α-trifluoromethylated ketones (J. Am. Chem. Soc., DOI: 10.1021/ja307783w). They used CuCF3, which they make from CuCl and fluoroform (CHF3), a process Grushin’s . . .

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