Issue Date: October 1, 2012
Copper Continues To Advance Trifluoromethylation
Copper-promoted trifluoromethylation reactions have been successful during the past three years, and researchers continue to broaden the scope of the chemistry and streamline procedures. Vladimir V. Grushin and coworkers at the Institute of Chemical Research of Catalonia, in Spain, now report a new synthesis of α-trifluoromethylated ketones (J. Am. Chem. Soc., DOI: 10.1021/ja307783w). They used CuCF3, which they make from CuCl and fluoroform (CHF3), a process Grushin’s . . .
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