Volume 90 Issue 42 | p. 11 | News of The Week
Issue Date: October 15, 2012 | Web Date: October 12, 2012

RNA G-Quadruplex Tagged Selectively

Chemical Biology: Work could lead to better understanding of mysterious folded RNA structure
Department: Science & Technology | Collection: Life Sciences
News Channels: Biological SCENE
Keywords: G-quadruplex, RNA, in situ click chemistry

Using an established biotagging technique, researchers have identified compounds that distinguish RNA from DNA versions of G-quadruplexes, folded nucleic acid structures. The approach could lead to a richer understanding of RNA G-quadruplexes, the biological role of which is mostly unknown.

The biotagging method, in situ click chemistry, uses known ligands for a class of target compounds to fish for selective ligands for a specific member of that class. The known ligands and a library of . . .

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