Issue Date: October 15, 2012 | Web Date: October 12, 2012
RNA G-Quadruplex Tagged Selectively
Using an established biotagging technique, researchers have identified compounds that distinguish RNA from DNA versions of G-quadruplexes, folded nucleic acid structures. The approach could lead to a richer understanding of RNA G-quadruplexes, the biological role of which is mostly unknown.
The biotagging method, in situ click chemistry, uses known ligands for a class of target compounds to fish for selective ligands for a specific member of that class. The known ligands and a library of . . .
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