Volume 90 Issue 45 | p. 9 | News of The Week
Issue Date: November 5, 2012

Old Tuberculosis Treatment Performs As Prodrug

Antibiotics: Metabolomics sheds new light on mechanism of aminosalicylic acid
Department: Science & Technology
News Channels: Biological SCENE
Keywords: tuberculosis, para-aminosalicylic acid, p-aminosalicylic acid, folate, folic acid, dihydropteroate synthase, metabolomics

A 60-year-old tuberculosis drug, p-aminosalicylic acid (PAS), acts as a prodrug rather than by inhibiting a key bacterial enzyme directly, according to a research report (Science, DOI: 10.1126/science.1228980).

PAS and other drugs of its era “have been around for a long time, and we really don’t know how they work,” says Stephen White, a professor of structural biology . . .

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