Volume 90 Issue 51 | p. 32 | Concentrates
Issue Date: December 17, 2012

Greened-Up Copper Addition Reactions

Micellar system enables sensitive organometallic reagents to carry out C–C couplings in water
Department: Science & Technology
News Channels: Organic SCENE, Materials SCENE, JACS In C&EN
Keywords: C-C coupling, organocopper, additon reaction, copper catalyst

There was once a time when chemists took extra precautions to keep air and moisture out of organometallic reactions, thinking that the reagents were overly sensitive to proton quenching and/or oxidation. But those days are gone. In one of the latest examples, a research team led by Bruce H. Lipshutz of the University of California, Santa Barbara, has created a reaction system to forge new C–C bonds using organocopper chemistry in . . .

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