Volume 90 Issue 6 | p. 6 | News of The Week
Issue Date: February 6, 2012

How Resveratrol Works

Biochemistry: Molecule’s metabolic effects result from acting directly on phosphodiesterases, not sirtuins
Department: Science & Technology | Collection: Life Sciences
News Channels: Biological SCENE
Keywords: Resveratrol, sirtuins, calorie restriction, aging

Chalk up the red wine compound resveratrol’s presumed health benefits to a direct blockade of phosphodiesterase enzymes, reports a multi-institution team (Cell, DOI: 10.1016/j.cell.2012.01.017). The researchers, led by NIH biologist Jay H. Chung, say their study clarifies confusing evidence about the biochemistry of resveratrol.

The study’s results point to new avenues of preventing age-associated metabolic diseases in people, says University of Wisconsin, Madison, calorie restriction researcher Richard . . .

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