Volume 90 Issue 7 | p. 37 | Concentrates
Issue Date: February 13, 2012

Domain Structure Of Cataract Amyloids

Two-dimensional IR spectroscopy reveals surprise for crystallin amyloid fibrils
Department: Science & Technology
News Channels: Analytical SCENE, Biological SCENE
Keywords: amyloids, fibrils, 2-D IR, multidimensional spectroscopy

Two-dimensional infrared spectroscopy reveals an unexpected structure for amyloid fibers formed from human γD-crystallin, which is a major component of cataracts (Proc. Natl. Acad. Sci. USA, DOI: 10.1073/pnas.1117704109). Martin T. Zanni of the University of Wisconsin, Madison; Sean M. Decatur of Oberlin College; and coworkers found this structure through a method that extends isotope-edited 2-D IR spectroscopy to entire proteins. In the past, isotopic . . .

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