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Web Date: April 30, 2012

Polymer Protects Proteins

Biochemistry: Glycopolymer guards proteins against heat and freeze-drying better than current stabilizers
Department: Science & Technology | Collection: Life Sciences
News Channels: Biological SCENE, JACS In C&EN
Keywords: trehalose, glycopolymers, protein stability, polyethylene glycol, PEG, protein drugs

Protein-based drugs can quickly lose activity during transport and storage. To prolong the proteins’ activity, drug firms add stabilizers, including polyethylene glycol and trehalose, a disaccharide that some organisms use to protect themselves from dehydration.

Now Heather D. Maynard and her research team at the University of California, Los Angeles, have combined the two molecules to create trehalose glycopolymers . . .

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Chemical & Engineering News
ISSN 0009-2347
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