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Web Date: April 27, 2012

Simple Probe Allows Drug Candidate Screening Without Labels

Drug Discovery: A small molecule fluoresces only when dislodged from a protein target by a drug molecule
Department: Science & Technology | Collection: Life Sciences
News Channels: Biological SCENE, Analytical SCENE, JACS In C&EN
Keywords: drug screening, fluorescence spectroscopy, high-throughput screen, label free

Researchers have designed a new small-molecule probe that binds to a protein and emits a fluorescent signal only when a drug molecule displaces it (J. Am. Chem. Soc., DOI: 10.1021/ ja301204z). The chemists hope that the probe will provide a simple, rapid method to screen drug candidates.

“There is a need for easy systems for screening drugs,” says . . .

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Chemical & Engineering News
ISSN 0009-2347
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