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Web Date: April 18, 2012

Spring-Loaded Nanoparticles Sense Proteases

Biosensors: A nanoparticle squeezed by peptides could help detect active enzymes associated with disease
Department: Science & Technology | Collection: Life Sciences
News Channels: Materials SCENE, Biological SCENE, Analytical SCENE, JACS In C&EN
Keywords: polymer nanoparticle, protease, biosensor, cancer

To spot early signs of cancer, some doctors want to monitor protease activity in the body. Previous research has shown that certain proteases turn on at the early stages of disease. Now researchers have developed a nanoparticle to help: It lights up only around active proteases (J. Am. Chem. Soc., DOI: 10.1021/ja301259v).

As cancer starts developing, few cancer . . .

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