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Web Date: April 24, 2012

Streamlining Tetrazine Synthesis

Organic Chemistry: Lewis acids make it easier to synthesize sought-after biochemical probes
Department: Science & Technology
News Channels: Analytical SCENE, Biological SCENE
Keywords: bioorthogonal chemistry, chemical biology, tetrazine, molecular probes

Thanks to zinc and nickel catalysts, a newfangled motif for biomolecule labeling might catch on more easily than it could before (Angew. Chem. Int. Ed., DOI: 10.1002/anie.201201117). Thus far, the labels, which feature nitrogen-rich rings called tetrazines, have been relegated to labs with the chemistry chops to work with the multistep and low-yielding syntheses required to make them. The advance might allow more . . .

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ISSN 0009-2347
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