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Web Date: June 6, 2012

Supersensitive Detection Of MicroRNAs

Nucleic Acids: Two methods spot the short strands of RNA at attomolar concentrations
Department: Science & Technology | Collection: Life Sciences
News Channels: Analytical SCENE, Biological SCENE, Materials SCENE, Nano SCENE
Keywords: microRNA, fluorescent detection, exponential isothermal amplification

MicroRNAs are short strands of RNA, about 22 bases long, that can regulate gene expression. Scientists think that monitoring levels of these nucleic acids could help doctors spot early stages of some cancers. Recently, two research groups have reported new methods to detect microRNA at concentrations around 1 attomolar (Anal. Chem., DOI: 10.1021/ac202405q and 10.1021/ac300483f).

Detecting miRNA is challenging because the . . .

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