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Web Date: July 19, 2012

NMR Detects Contaminants In Heparin

Drug Safety: Analytical method can spot adulterated anticoagulant
Department: Science & Technology | Collection: Life Sciences
News Channels: Analytical SCENE, Biological SCENE
Keywords: heparin, chondroitin sulfate, drug contamination, NMR, nuclear magnetic resonance spectroscopy, quality control

Dozens of people in the U.S. died in 2007 and 2008 when they received contaminated doses of heparin, a common blood thinner. To help regulators spot future cases of adulteration, researchers have developed a nuclear magnetic resonance method that exposes any additive in heparin samples (Anal. Chem., DOI: 10.1021/ac301428d).

Medical heparin is a polysaccharide extracted from the intestines of pigs. The exact structure . . .

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