Volume 91 Issue 26 | p. 20 | Concentrates
Issue Date: July 1, 2013

A Potent Step Toward Banishing HIV

Modifications to natural product produce more powerful compounds aimed at eradicating virus
Department: Science & Technology
News Channels: Biological SCENE, Organic SCENE
Keywords: prostratin, HIV, AIDS, analog

By subtly tweaking the structure of the natural product prostratin, chemists have come up with molecules that could help eradicate AIDS (Proc. Natl. Acad. Sci. USA 2013, DOI: 10.1073/pnas.1302634110). The current antiretroviral cocktail used to treat HIV only attacks active virus. People must take these drugs for life because the virus also adopts a dormant provirus form, which hides . . .

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