Volume 91 Issue 31 | p. 30 | Concentrates
Issue Date: August 5, 2013

DNA Robots Detect Blood Cell Types

Combination of cell-surface markers triggers molecular cascade that results in a fluorescent signal
Department: Science & Technology
Keywords: DNA robots, cell detection

Different types of immune cells in the blood can be recognized for diagnostic and therapeutic purposes by the glycoprotein markers on their surface. For example, B cells typically express the markers CD45 and CD20, whereas T cells have CD45 and CD3. In a new recognition approach—developed by Sergei Rudchenko of the Hospital for Special Surgery in New York City, Milan N. Stojanovic of Columbia University, and coworkers—a set of molecular robots made of double-stranded DNA-antibody . . .

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