Volume 91 Issue 33 | pp. 26-27
Issue Date: August 19, 2013

Enzyme By Design

Computational modeling and directed evolution work together to jack up the activity of catalytic proteins
Department: Science & Technology
News Channels: Biological SCENE
Keywords: computational protein design, directed evolution

Natural enzymes have an exquisite ability to selectively and efficiently catalyze biochemical processes. Scientists have a great interest in harnessing that ability and putting these protein catalysts to work in synthetic applications. To do so, they have been using computer modeling to design enzymes for target reactions and then synthesizing them in the lab. But those enzymes are falling far short of the talents of natural enzymes.

By instead using the designed enzymes as a . . .

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