Issue Date: August 19, 2013
New Sensor Tracks Methylglyoxal
Methylglyoxal (MGO), a ubiquitous metabolite produced by living cells, plays a poorly understood role in numerous diseases, such as diabetes, and is implicated in chemotherapy resistance. Until now, there hasn’t been a good way to monitor MGO in living cells. David A. Spiegel and Tina Wang of Yale University and colleagues have synthesized a molecule that selectively attaches to MGO and renders the complex fluorescent (J. Am. Chem. Soc. 2013, DOI: . . .
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