Volume 91 Issue 44 | p. 29 | Concentrates
Issue Date: November 4, 2013

Complex Ring Systems Made Quick And Easy

Chemists report new ways to make structurally diverse carbocycles as building blocks for natural product and pharmaceutical syntheses
Department: Science & Technology
News Channels: Organic SCENE
Keywords: cyclopentane, natural product, cascade synthesis, domino synthesis

Organic chemists are always on the lookout for more efficient ways to make useful amounts of bioactive natural products or to synthesize complex molecules that can serve as pharmaceutical agents. Making molecules containing structurally diverse six-membered rings is a common feat in these preparations, but constructing five-membered carbocycle systems has lagged behind. Two research groups now report methods to quickly assemble cyclopentyl structural motifs. A team led by Daniel Romo of Texas . . .

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