Volume 91 Issue 46 | p. 5 | News of The Week
Issue Date: November 18, 2013

Unfolding Diabetes

Spectroscopy: Disrupting amyloid fibril intermediate could lead to prevention, new treatments
Department: Science & Technology | Collection: Life Sciences
News Channels: Biological SCENE, Analytical SCENE
Keywords: amyloid, islet, amylin, fibril, plaque, diabetes

A number of diseases—including diabetes, Alzheimer’s, and Parkinson’s—are associated with polypeptides that misfold and aggregate into fibrils that further clump together to form plaques. Researchers have now characterized the structure of an intermediate that leads to fibrils in the folding pathway of a polypeptide implicated in type 2 diabetes.

Disrupting formation of the intermediate structure may provide a new target for preventing or treating the disease, which is a growing public health problem. Type 2 . . .

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