Volume 91 Issue 47 | p. 7 | News of The Week
Issue Date: November 25, 2013

Cancer Protein Meets Its Match

Drug Discovery: Researchers find first potent inhibitors of cancer-associated Ras protein
Department: Science & Technology
News Channels: Biological SCENE
Keywords: Ras, cancer, lung cancer, protein inhibitor, drug discovery

Scientists have devoted lots of time and money trying to find inhibitors of human Ras proteins. About 30% of cancers depend on mutated versions of Ras for growth and survival, making Ras mutants appealing cancer drug targets.

The fruits of these efforts have been molecules that bind Ras mutants only weakly or inhibit them indirectly by preventing the proteins from localizing in cell membranes, where Ras signaling occurs. But neither type of inhibitor has proven . . .

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