Volume 91 Issue 49 | p. 30 | Concentrates
Issue Date: December 9, 2013

Vaccines Using Toxin-Absorbing Nanosponges

Researchers leverage the cell-membrane affinity of a bacterium-secreted toxin to make a live vaccine based on coated nanoparticles
Department: Science & Technology
News Channels: Biological SCENE, Materials SCENE, Nano SCENE
Keywords: bacteria, toxin, MRSA, vaccine, immunization, antibody, nanoparticle

As vaccines against infectious diseases, nanoparticles with coatings that soak up unaltered bacterial protein toxins like a sponge could be more effective than heat-deactivated toxins, according to a report by Liangfang Zhang and coworkers at the University of California, San Diego (Nat. Nanotechnol. 2013, DOI: 10.1038/nnano.2013.254). Some bacterial toxins operate by embedding themselves in cell membranes, creating pores that leak cellular contents. Heating the . . .

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