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Web Date: July 2, 2013

Microfluidic Device Helps Scientists Capture Snapshots Of Biomolecule Interactions

Biophysics: By rapidly diluting solutions of biomolecule complexes, the device enables single-molecule studies before the molecules disassemble
Department: Science & Technology | Collection: Life Sciences
News Channels: Analytical SCENE, Biological SCENE
Keywords: single-molecule fluorescence microscopy, microfluidics, soft lithography, protein complexes

Inside our cells, proteins and other biomolecules come together to form molecular complexes as part of the mechanisms that keep the cells running. These interactions sometimes are fleeting. For example, as new proteins are synthesized, the growing chain interacts off and on with other proteins called chaperones that ensure the new one folds correctly. A new microfluidic device could help researchers study short-lived molecular complexes involved in key biological processes, capturing . . .

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Chemical & Engineering News
ISSN 0009-2347
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