Volume 92 Issue 13 | p. 25 | Concentrates
Issue Date: March 31, 2014

A Practical Path To Morphine Alkaloids

After decades of trying, chemists have whittled down the total synthesis of morphine alkaloids to an almost practical length
Department: Science & Technology
News Channels: Organic SCENE
Keywords: morphine, codeine, natural products, total synthesis, opium

Morphine is an indispensable narcotic drug derived from the opium poppy that has been used for centuries to relieve intense pain. The compound also serves as a precursor to a stable of other useful narcotics, such as codeine and hydromorphone. But chemists have struggled to devise a reasonably short synthetic pathway that can be used to produce morphine on an economically viable commercial scale. Building on decades of research by multiple groups, Vimal Varghese and . . .

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