Complementary techniques enhance molecules with methyl groups to aid the search for bioactivity-enhancing sweet spots
Medicinal chemists invoke the “magic methyl effect” whenever they find that adding a single methyl group profoundly improves a molecule’s biological effectiveness—sometimes by as much as 100-fold. Researchers want late-stage techniques for attaching methyl groups so they don’t have to start syntheses from scratch. Now, two complementary reports offer that possibility. Reasoning that methylated products would be difficult to separate from similar-looking starting materials, Phil S. Baran of Scripps Research Institute, . . .
To view the rest of this content, please log in with your ACS ID.
- Chemical & Engineering News
- ISSN 0009-2347
- Copyright © American Chemical Society