Volume 92 Issue 24 | p. 7 | News of The Week
Issue Date: June 16, 2014 | Web Date: June 13, 2014

GABA Receptor Structure Solved

Structural Biology: Crystal structure of human receptor uncovers previously unknown agonist
Department: Science & Technology | Collection: Life Sciences
News Channels: Biological SCENE
Keywords: structural biology, crystal structure, neurotransmitter, ion channel

Despite the importance of γ-aminobutyric acid type A (GABAA) receptors as drug targets for a wide range of health conditions, a crystal structure has never been determined—until now. Paul S. Miller and A. Radu Aricescu, structural biologists at the University of Oxford, in England, have obtained the first crystal structure of a human GABAA receptor, at 3-Å resolution (Nature 2014, DOI: 10.1038/nature13293).

Drugs . . .

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