Volume 92 Issue 3 | p. 10 | News of The Week
Issue Date: January 20, 2014

Spotting Many Different Proteins On Single Cells

Analytical Biochemistry: DNA-based sensing of multiple proteins could aid personalized medicine
Department: Science & Technology
News Channels: Analytical SCENE, Biological SCENE
Keywords: DNA barcodes, fluorescence, protein detection, antibodies

Using antibodies and little pieces of DNA, a new technique detects hundreds of different proteins on individual cells. It could be used to study protein variations—on different cells in the same tumor, for example—analyze responses to drugs, and diagnose diseases.

Ralph Weissleder of Massachusetts General Hospital (MGH) and coworkers developed the technique and demonstrated its ability to identify proteins on cells from patients with lung or skin cancer (Sci. Transl. Med. . . .

To view the rest of this content, please log in with your ACS ID.

Chemical & Engineering News
ISSN 0009-2347
Copyright © American Chemical Society